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DTSTAMP:20241120T082409Z
LOCATION:HG F 26.5
DTSTART;TZID=Europe/Stockholm:20240604T163000
DTEND;TZID=Europe/Stockholm:20240604T170000
UID:submissions.pasc-conference.org_PASC24_sess122_msa160@linklings.com
SUMMARY:Mutation Count Alone does not Predict the Severity of Common Varia
 nts of SARS-CoV-2
DESCRIPTION:Minisymposium\n\nDaniel Janies, Shirish Yasa, Sayal Guirales-M
 edrano, Denis Jacob Machado, and Colby Ford (University of North Carolina,
  CIPHER Center)\n\nSARS-CoV-2 Omicron variants BA.2.86 and JN.1 have mutat
 ions that have raised concerns over their health impact. Genomic surveilla
 nce of JN.1 has shown it to be the dominant variant circulating in the USA
 .\n\nEmpirical studies on immune evasion and transmissibility on BA.2.86 a
 nd JN.1 are contradictory. To assess immune evasion of BA.2.86 and JN.1, w
 e performed in silico analyses of the Receptor Binding Domain (RBD) of SAR
 S-CoV-2 variants. We calculated the relative binding affinity of neutraliz
 ing antibodies derived from vaccinated patients, infected patients, and th
 erapy to the RBDs. To assess transmissibility, we calculated the relative 
 binding affinity of the RBDs to the Angiotensin Converting Enzyme-2 (ACE2)
  host cell receptor.\n\nWe found minor changes in some binding affinity me
 trics for neutralizing antibodies and ACE2 to RBDs of BA.2.86 and JN.1. Ho
 wever, most changes are not statistically significant. We conclude that BA
 .2.86 and JN.1 have inconsequential changes in immune evasion or transmiss
 ibility. We caution that genomic surveillance that counts mutations and th
 e prevalence of a variant does not reveal the functional and health impact
 s of the variant. In concordance with our results, there has not been a su
 rge on hospitals in the USA with the rise in the prevalence of BA.2.86 and
  JN.1.\n\nDomain: Chemistry and Materials, Engineering, Life Sciences, Com
 putational Methods and Applied Mathematics\n\nSession Chairs: John Anderso
 n Garcia Henao (University of Bern, ARTORG Center for Biomedical Engineeri
 ng Research) and Kary Ann del Carmen Ocaña Gautherot (LNCC)
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